Brevital (methohexital) Mnemonic
BREVITAL
Barbiturate
Rapid onset
ECT to decrease seizure threshold
Very short acting
Intravenous or rectal administration (in pediatrics)
Twice as potent as thiopental
Anesthesia (ultrashort-acting)
Limited duration of action 3-7 minutes
Here are some key points about Methohexital that might be useful for your board exam review:
- General Category: Barbiturate anesthetic.
- Brand Names: Brevital, Brietal.
- Chemical Structure: Barbiturate derivative.
- Mechanism of Action: Enhances GABA-mediated inhibition at GABA-A receptors, leading to sedation and hypnosis.
- Molecular Formula: C14H17N2NaO3.
- Onset and Duration: Rapid onset (within seconds), short duration of action due to redistribution.
- Indications: Induction of general anesthesia, procedural sedation.
- Dosage: Induction dose typically 1-2 mg/kg IV.
- Metabolism/Excretion: Metabolized in the liver, excreted via urine.
- Side Effects: Respiratory depression, hypotension, excitatory symptoms (e.g., cough, hiccup, muscle tremors) upon induction.
- Contraindications/Cautions: Acute intermittent porphyria, severe cardiovascular disease.
- Additional Notes: High lipid solubility contributes to its rapid onset and short duration.
For more anesthesiology mnemonics check this mnemonic book.
This post covers the points you need to know for your board exams as well as for teaching residents on the daily rounds. Medical professionals can't use the information here to treat their patients nor people can use the information her to treat themselves. If you are having any medical issues, contact your local emergency services or your primary care provider. Please refer to your doctor for medical advice.