Desflurane (Suprane) mnemonic:
SUPRANE
Short duration of action 8 minutes
Unpleasant odor
Production of CO
Rapid onset of action 1-2 minutes
Airway irritability
Not nephrotoxic
Evaluate for malignant hyperthermia
Here is some information about Desflurane for your board exam:
- General Category: Inhalational anesthetic gas.
- Brand Name: Suprane.
- Chemical Structure: Fluorinated methyl ethyl ether.
- Mechanism of Action: Modulates GABA-A receptors and glycine receptors, inhibits excitatory NMDA glutamate receptors and nicotinic ACh receptors, activates K+ channels, and inhibits voltage-gated Na+ and Ca2+ channels.
- Molecular Formula: C3H2F6O.
- Vapor Pressure: 669 mmHg.
- Blood/Gas Partition Coefficient: 0.42.
- Minimum Alveolar Concentration (MAC): 6%.
- Metabolism/Excretion: Minimal metabolism, primarily excreted via the lungs.
- Side Effects: Bronchospasm, laryngospasm, coughing, increased heart rate, hypertension, decreased cerebral metabolic rate of oxygen (CMRO2), decreased intracranial pressure (ICP), increased cerebral blood flow (CBF), and prolonged QT interval.
- Contraindications/Cautions: Trigger for malignant hyperthermia (MH), airway irritant (avoid as induction agent), sympathetic stimulation.
- Additional Notes: Most pungent volatile anesthetic, minimal risk of hepatitis and nephrotoxicity.
For more anesthesiology mnemonics check this mnemonic book.
This post covers the points you need to know for your board exams as well as for teaching residents on the daily rounds. Medical professionals can't use the information here to treat their patients nor people can use the information her to treat themselves. If you are having any medical issues, contact your local emergency services or your primary care provider. Please refer to your doctor for medical advice.